Yoho National Park is located in the Canadian Rocky Mountains along the western slope of the Continental Divide of the Americas in southeastern British Columbia. Yoho NP is bordered by Kootenay National Park on the southern side and Banff National Park on the eastern side in Alberta. The name Yoho comes from the Cree word for awe and wonder.

Yoho covers 1,313 km2 (507 mi2) and it is the smallest of the four contiguous national parks. Yoho, together with Jasper, Kootenay and Banff National Parks, along with three British Columbia provincial parks—Hamber Provincial Park, Mount Assiniboine Provincial Park, and Mount Robson Provincial Park—form the Canadian Rocky Mountain Parks World Heritage Site. The park's administrative and visitor centre are located in the town of Field, British Columbia, beside the Trans-Canada Highway.